These have quickly become my go-to shoe for everything from short trail intervals to 20 mile long runs. (Beyond the 50km distance, I would go for more cushion, like Dynafit's Ultra 100's). The fit is great right out of the box - provided you size up. I went up one full US size. Through about 100 miles so far the Vibram rubber looks good as new. I've found them to have great traction on technical trail and scrambles, without being too aggressive of tread for my home Wasatch trails. The upper is cool, comfortable and light but still seems plenty durable.
These are the slightly less race-oriented version of the DNA Alpine, but I think the average purchaser will appreciate the slightly lower price, increased durability and same light-weight offering of this shoe.